Below is a list of feature films that Oscar Isaac has starred in. They are listed in reverse-chronological order, with the most recent ones last. Click on the titles to read more about each project individually.
| 1996 | Illtown | Pool Boy |
| 2002 | All About the Benjamins | Francesco |
| 2005 | Lenny the Wonder Dog | Fartman (as Oscar Isaac Hernandez) |
| 2006 | Pu-239 | Shiv |
| 2006 | The Nativity Story | Joseph |
| 2007 | The Life Before Her Eyes | Marcus |
| 2008 | Che: Part One | Interpreter (as Óscar Isaac) |
| 2008 | Body of Lies | Bassam |
| 2009 | Agora | Orestes |
| 2009 | Balibo | José Ramos-Horta |
| 2010 | Robin Hood | Prince John |
| 2011 | Sucker Punch | Blue Jones |
| 2011 | Star Tours: The Adventures Continue (Short) | Poe Dameron |
| 2011 | Drive | Standard |
| 2011 | W.E. | Evgeni |
| 2011 | 10 Years | Reeves |
| 2012 | For Greater Glory: The True Story of Cristiada | Victoriano ‘El Catorce’ Ramirez |
| 2012 | Revenge for Jolly! | Cecil |
| 2012 | The Bourne Legacy | Outcome #3 |
| 2012 | Won’t Back Down | Michael Perry |
| 2013 | Inside Llewyn Davis | Llewyn Davis |
| 2013 | In Secret | Laurent |
| 2013 | Making a Scene (Short) | Man |
| 2014 | Trentemøller: Gravity (Video short) | Mr. Carpool |
| 2014 | The Two Faces of January | Rydal |
| 2014 | Ticky Tacky (Short) | Lucien |
| 2014 | A Most Violent Year | Abel Morales |
| 2014 | Ex Machina | Nathan |
| 2015 | Mojave | Jack |
| 2015 | Star Wars: The Force Awakens | Poe Dameron |
| 2016 | X-Men: Apocalypse | En Sabah Nur / Apocalypse |
| 2016 | Lightningface (Short) | Basil Stitt |
| 2016 | The Promise | Mikael Boghosian |
| 2017 | Suburbicon | Bud Cooper |
| 2017 | Star Wars: The Last Jedi | Poe Dameron |
| 2018 | Annihilation | Kane |
| 2018 | Operation Finale | Peter Malkin |
| 2018 | At Eternity’s Gate | Paul Gauguin |
| 2018 | Life Itself | Will |
| 2019 | Triple Frontier | Santiago |
| 2019 | The Addams Family | Gomez Addams (voice) |
| 2019 | Star Wars: Episode IX | Poe Dameron |